Job Description

Associate Director - Medicinal Chemistry

Vilya is a computational biotechnology company creating a novel class of medicines to precisely target disease biology. We believe computational approaches are an integral, if not foundational, component of drug discovery and development.

We are harnessing the power of our platform to go after previously impossible targets in an array of indications. Vilya’s ultimate goal is to solve some of the most challenging unmet medical needs that exist today.

Our Vision: Harness a revolution in technology and biology to better human health.

Our Mission: Build an independent, leading biotech company founded on intelligent drug design to cure the incurable.

We are seeking a highly-skilled and enthusiastic Associate Director of Medicinal Chemistry to join Vilya’s Chemistry team in South San Francisco. Reporting to our VP of Chemistry, this full-time onsite position will play a key role in expanding our platform technology and advancing orally available macrocycles into the clinic.

RESPONSIBILITIES:

• Leadership of the medicinal chemistry function within multidisciplinary project teams, with potential for project team leadership
• Advancement of screening hits through hit-to-lead and lead optimization for the delivery of development candidates for preclinical evaluation
• CRO management for the preparation of key building blocks, high value intermediates, and control compounds
• Evaluation and implementation of state of the art synthetic methodologies for the production of novel chemical structures
• Proactive collaboration and effective communication with cross-functional teams
• Frequent presentation of progress updates to the chemistry group, cross-functional research teams, and corporate leadership
• Effective written communication as required for patent filings, company reports, and scientific publications
• Maintain a culture of compliance to all corporate policies, including all relevant safety and environmental regulations

PREFERRED QUALIFICATIONS:

• PhD in organic or medicinal chemistry
• 7+ years post-PhD experience in an academic, biotechnology, or pharmaceutical setting
• Expertise in the synthesis, purification, and characterization of complex organic small molecules including methodology development and reaction optimization
• Experience with SBDD
• Demonstrated ability to deliver development candidates for preclinical evaluation
• Management of external FTEs in synthetic or medicinal chemistry
• Management of internal direct reports
• Prior experience as medicinal chemistry lead on a project team is strongly preferred
• Experience with solution- and/or solid-phase peptide synthesis is preferred
• Enthusiastic and self-motivated with strong time management and multitasking skills
• Scientifically curious and eager to learn
• Positive attitude and willingness to do whatever is needed to meet deliverables and advance projects

VILYA BENEFITS:

• Opportunity to work in a disruptive startup with a talented, experienced, and growing team of dedicated individuals
• 401(k) plan with employer matching for contributions
• Stock options
• Excellent medical, dental, and vision coverage
• Support to attend professional conferences that are meaningful to your career growth

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